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Bishr Omary, PhD, MD, this issue was developed by internationally renowned experts in the pancreas: Diane M. Simeone, MD, associate editor for Gastroenterology, and Stephen J. Pandol, MD, Gastroenterology editorial board member. “Our goal in this special issue of Gastroenterology is to present readers with a variety of topics related to the exocrine pancreas and its disorders that will spur innovations and lead to critical new treatments,” said Dr. Simeone from the University of Michigan Medical Center in Ann Arbor, MI. The pancreas has two main functions – the exocrine function, which helps in digestion, and the endocrine function, which helps regulate blood sugar. With new findings on how diseases affect the exocrine pancreas being released at a rapid pace, the field of gastroenterology is approaching the crossroads of converting the understanding of how pancreatic diseases work into new treatments for patients with these diseases. At this critical time, the Gastroenterology board of editors unanimously decided that it was necessary to devote the 2013 13th issue to the pancreas to provide readers with important and state-of-the-art information about pancreatic biology and disease. Comprised of classic review articles and insightful commentaries from leading authorities in both the basic and clinical sciences, this supplement addresses critical topics in both domains, outlines the challenges that lie ahead and dissects the approaches that may be used to advance the care of patients with pancreatic disease. This year’s issue is divided into two sections. The first section includes topics of basic investigation related to biology and disease mechanisms; the second is focused on clinical manifestations and management of pancreatic disorders. The commentaries and reviews, and their distinguished authors, are as follows: A. Biology of the Pancreas “The Nobel Pancreas: A Historical Perspective” by John Williams.