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In patients with ulcerative colitis, they have been shown to be very effective in inducing and maintaining remission of disease. Levels of 5-ASA in the lining of the bowels have been shown to predict efficacy and possibly act as a marker for clinical endpoints in patients with disease. A clinical trial was performed by Haines et al, to try and determine a simple, yet sensitive and reproducible method for detection of 5-ASA in the lining of the bowel. Specific concentrations of 5-ASA were added to biopsies (tissue samples) of the lining of the colon. From the study, clear, reproducible peaks were achieved at certain wavelengths. These peaks were significantly sensitive for 5-ASA. What we need to do now is to apply these results in a clinical context. Genes Implicated in IBD – IL23R is an IBD Susceptibility Gene (confirmation in an Australian cohort) and GLI1 gene a Risk Factor for Ulcerative Colitis With advances in research and from results of clinical studies, additional insight into the causes and genetics behind ulcerative colitis has been obtained. For example, variations in particular receptors such as the IL 23 receptor has recently been shown to be associated with both Crohn’s and ulcerative colitis. Another gene called the GLI1 gene plays a significant role in the formation and maintenance of a healthy lining for our gut. Defects in the GLI1 gene have been implicated in patients with ulcerative colitis.